Modulators of inwardly rectifying potassium channels

摘要

The present invention provides the use of a substance which modulates inwardly rectifying potassium channel (Kir) activity of a polypeptide, which polypeptide comprises: SL LI(a) the amino acid sequence of SEQ ID NO: 2; or LI(b) a variant thereof which is a potassium channel activated by hyperpolarisation of cell membrane potential below the reversal potential for potassium; or LI(c) a fragment of (a) or (b) which is a potassium channel activated by hyperpolarisation of cell membrane potential below the reversal potential for potassium; /SL in the manufacture of a medicament for the treatment or prophylaxis of a cerebellar or spinocerebellar disorder, a thyroid disorder or a kidney disorder.