There is provided a compound of formula I:whereinX represents O or NR5 R4 represents H, halo, cyano, nitro, halo(loweralkyl), OR6, OC(O)R7, C(O)R8, C(O)OR9, C(O)NR10R11, NR12R13, NR16Y(O)R17, N[Y(O)R17]2, SOR18, SO2R19, C(O)AZ, lower alkyl, lower alkenyl, lower alkynyl, Het, alkylHet, aryl, alkylaryl (which latter seven groups are all optionally substituted with one or more substituents selected from halo, cyano, nitro, lower alkyl, halo(loweralkyl), OR6, OC(O)R7, C(O)R8, C(O)OR9, C(O)NR10R11, NR12R13 and SO2NR14R15)which are useful in the curative and prophylactic treatment of a medical condition for which inhibition of a cyclic guanosine 3',5'-monophosphate phosphodiesterase (e.g., cGMP PDE5) is desired.
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机译:提供了式I的化合物:其中X表示O或NR 5 R 4表示H,卤素,氰基,硝基,卤素(低级烷基),OR 6,OC(O)R 7,C (O)R 8,C(O)OR 9,C(O)NR 10 R 11,NR 12 R 13,NR 16 Y(O)R 17 >,N [Y(O)R 17] 2,SOR 18,SO2R 19,C(O)AZ,低级烷基,低级烯基,低级炔基,Het,烷基Het,芳基,烷基芳基(后者七个基团全部任选地被一个或多个选自卤素,氰基,硝基,低级烷基,卤代(低级烷基),OR 6,OC(O)R 7,C(O)R 8的取代基取代, C(O)OR 9,C(O)NR 10 R 11,NR 12 R 13和SO 2 NR 14 R 15)可用于肝硬化的预防和治疗希望抑制环状鸟苷3',5'-单磷酸磷酸二酯酶(例如cGMP PDE5)的医学病症。
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