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Lipid-based drug delivery systems containing phospholipase A2 degradable lipid derivatives and their use in therapy
Lipid-based drug delivery systems containing phospholipase A2 degradable lipid derivatives and their use in therapy
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机译:含磷脂酶A2可降解脂质衍生物的基于脂质的药物递送系统及其在治疗中的用途
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摘要
The present invention relates to a lipid based drug delivery system for administration of a drug substance, wherein the drug substance is incorporated in the system, said system including lipid derivatives which has (a) an aliphatic group of a length of at least 7 carbon atoms and an organic radical having at least 7 carbon atoms, and (b) a hydrophilic moiety, where the lipid derivative furthermore is a substrate for extracellular phospholipase A2 to the extent that the organic radical can be hydrolytically cleaved off, said system having included therein lipopolymers or glycolipids so as to present hydrophilic chains on the surface of the system.
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