(57) Abstract As for this invention, formula (4) racemic alcohol; The formula which makes the racemization reaction of the aforementioned racemic alcohol promote the chemical compound which is displayed with (1), (2) and (3) the ruthenium complex compound where (1), (2) and (3) is chosen from the group; The lipase which the acylation does one of enanchioma of the aforementioned racemic alcohol selectively; The acyl basic donor which supplies the acyl basis to the aforementioned lipase; Mixing and reacting, it is production method of kiraruesuteru which features that it makes kiraruesuteru which with formula (100) is displayed. In formula (1), Q is (a) or (b), X Br and Cl or is I; In formula (2), Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8, Y9, Y10, as for Y11 and Y12, the hydrogen atom, or carbon count alkyl group 1 - 5, as for X Br and Cl or it is I in the respective independence; In formula (3), Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8, Y9, Y10, Y11 and Y12, the hydrogen atom, or carbon count alkyl group 1 - 5, X Br and Cl or to be I in the respective independence, R1, R2 and R3, the alkyl group which is possible to be substituted by the respective independence, the aryl basis which is possible to be substituted, or to be chosen from the group which consists of shikuroarukiru which is possible to be substituted in formula (4) and (5), R1 and R2R1 and R3, R2 and R3 has been allowed to have become mutually annulation. The alkyl group and the aryl basis, the aforementioned substituent of shikuroarukiru, hetero atom such as halogen atom, is the cyano basis.
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