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Mapping of individual ATP-binding domains by inducing CTL in vivo without CD4 + T cells by heat shock protein fusion protein
Mapping of individual ATP-binding domains by inducing CTL in vivo without CD4 + T cells by heat shock protein fusion protein
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机译:通过热激蛋白融合蛋白诱导体内无CD4 + T细胞的CTL来绘制单个ATP结合域的图谱
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摘要
The present invention relates to a method of inducing a CD8+ CTL response to a molecule in an individual deficient in CD4+ T cells comprising administering to the individual art hsp or a portion of an ATP binding domain of an hsp joined to the molecule. In one embodiment, the present invention relates to a method of treating HIV in an individual deficient in CD4+ T cells comprising administering to the individual an hsp or a portion of an ATP binding domain of an hsp joined to the molecule. Also encompassed by the present invention is a method of inducing a CD4+ independent CTL response in an individual comprising administering to the individual a portion of an ATP binding domain of an hsp joined to the molecule. The present invention also relates to a method of inducing a CD8+ CTL response in an individual comprising administering to the individual a portion of an ATP binding domain of an hsp joined to the molecule. In addition, the present invention relates to a composition characterized by a portion of an ATP biding domain of an hsp joined to a molecule.
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