Peptide analogs as selective inhibitors of the thrombin activity of protease-activated receptor 1

摘要

The invention relates to inhibiting human platelet aggregation, thrombosis and cell activation mediated by PAR1 with peptide analogs corresponding to those of Formula I and II, wherein Formula I is:wherein:Z4 is any naturally occurring amino acid, excluding cysteine; and wherein Formula II is:wherein:Z4 is any naturally occurring amino acid, excluding cysteine.