The halo glucuronic acid ester intermediate field was used, production method of morphine -6- gurukuronido and its analog

摘要

(57) Abstract Topic Appropriate, the new member where it is the intermediate field where the morphine which is substituted is appropriately substituted, namely, it possesses the general structure which connects with 1- harogurukuronetoesuteru under iodine or iodonium compound existing, the morphine - 6 - production method of gurukuronido and its related chemical compound is offered. Solutions The method of producing the related chemical compound which under existing of the iodine or iodonium compound, features the step which makes 1- halo glucuronic acid ester the morphine connect which appropriately is substituted, possesses morphine -6- gurukuronido and the general structure which is displayed with the below-mentioned formula 1. The above-mentioned production method, the above-mentioned formula (1) converting R¹ to the hydrogen atom, and/or, are times when the process which removes the ester basis from the gurukuronitsuku residue of R² is accompanied.