Uses the said manner in order to diagnose the test kit in order to execute manner and the said manner which measure the collagen fragment in the body fluids and the existence of the disease which it is related to the metabolism of means, and the collagen the mannered application

摘要

(57) A method of measuring collagen fragments in body fluids and which comprises contacting it with an immunological binding partner for at least one to collagen fragment samples SUMMARY body fluid, wherein the immunological binding partner, substantially The measurement method is to contain the possible sites for cross-linking and immunoreactive with synthetic peptides having a sequence derived from collagen. Either as active fragment thereof immunologically or as whole antibodies, epidemiological binding partner is incorporated into the measurement method for quantifying the collagen fragments in the sample. It may also directly contact the synthetic peptide other than that contacting the one or more immunological binding partners, the sample corresponds. The present invention includes specific means and test kit for carrying out the method. In addition, I will describe and also described the structure of the specific peptide.