LOW-DOSE ORAL CONTRACEPTIVE WITH SUSTAINED EFFICACY THAT INDUCES AMENORRHEA

摘要

PROBLEM TO BE SOLVED: To provide a new estrogen-progestin combination and/or regimen for oral contraceptive use which maintains the efficacy and performs control of endometrial bleeding, the continuous use of which leads to amenorrhea (a lack of vaginal bleeding). SOLUTION: A method of female contraception involves administering a combination of estrogen and progestin continuously for more than a year in which the daily amounts of estrogen and progestin are equivalent to about 5 to 35 mcg of ethinyl estradiol and about 0.025 to 10 mg of norethindrone acetate, respectively. The advantages include lack of menstrual bleeding, less patient anemia, less total exposure to medication when compared to a 35 g (low dose)-containing oral contraceptive, reduced risk of endometrial cancer, high compliance rates and lifestyle convenience for patients who desire less uterine bleeding each year or longer.