首页>
外国专利>
METHOD FOR MAINTENANCE AND PROPAGATION OF GERMLINE STEM CELLS USING MEMBERS OF THE TFG-B FAMILY OF GROWTH FACTORS
METHOD FOR MAINTENANCE AND PROPAGATION OF GERMLINE STEM CELLS USING MEMBERS OF THE TFG-B FAMILY OF GROWTH FACTORS
展开▼
机译:利用生长因子TFG-B家族的成员维持和繁殖生殖干细胞的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The TGF-&bgr; family of growth factors, particularly the bone morphogenetic protein (BMP)-2/4 homolog decapentaplegic (dpp), are specifically required to maintain germline stem cells and promote their division. Overexpression of dpp blocks germline stem cell differentiation. Mutations in dpp or its receptor saxophone accelerate stem cell loss and retard stem cell division. dpp signaling is directly received by germline stem cells, and thus dpp signaling helps define a niche that controls germline stem cell proliferation.
展开▼