首页>
外国专利>
Variants of IL-1 beta gene and CD46 gene for diagnosing unexplained recurrent pregnancy loss
Variants of IL-1 beta gene and CD46 gene for diagnosing unexplained recurrent pregnancy loss
展开▼
机译:IL-1β基因和CD46基因的变异体,用于诊断无法解释的复发性流产
展开▼
页面导航
摘要
著录项
相似文献
摘要
The discovery of an association between two variants of the human interleukin-1 gene (IL1B) beta promoter region and a variant of the CD46 gene intron 1 and T-helper type 1 immunity in unexplained recurrent pregnancy loss (URPL) is disclosed. These two IL1B variants are characterized by a base C at position-511 (IL1B-511C) and a base T at position-31 (IL1B-31T) from the transcriptional start site of the IL1B gene. The CD46 gene intron 1 variant is characterized by a change in the HindIII site in this intron. These IL1B promoter variants and CD46 gene intron 1 variants, and reagents for detecting said variants, are useful as diagnostic markers for the diagnosis and management of recurrent pregnancy loss. Accordingly, the invention provides methods and compositions which identify these variants for determining a subject's propensity for having reproductive failure and, particularly, reproductive failure attributed to Th1 cytokines.
展开▼