A new protein named Tankyrase II is described in this disclosure. Sequences for the human Tankyrase II cDNA and the protein translation product are provided. Also provided are species homologs, muteins, related nucleic acids, peptides, and drug screening assays. Tankyrase II interacts with telomere-associated proteins, thereby affecting telomerase activity and potentially telomere length. The materials and techniques provided in this disclosure allow Tankyrase II activity to be studied in vitro and manipulated inside cells—to the potential benefit of clinical conditions associated with a defect in telomerase activity, or the replicative capacity of affected cells.
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机译:在本公开中描述了一种新的蛋白,名为坦科聚合酶II。提供了人Tankyrase II cDNA和蛋白质翻译产物的序列。还提供了物种同源物,突变蛋白,相关核酸,肽和药物筛选测定法。 Tankyrase II与端粒相关蛋白相互作用,从而影响端粒酶活性和潜在的端粒长度。本公开中提供的材料和技术允许在体外研究Tankyrase II的活性并在细胞内进行操纵-从而获得与端粒酶活性或受影响细胞的复制能力缺陷相关的临床病症的潜在益处。
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