Analogs of terpene trilactones from ginkgo biloba for bioorganic and imaging studies

摘要

A compound having the structure: chemistry chemdraw filechemistry mol file;wherein R₁ is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; ;wherein R₂ is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; ;wherein R₃ is H or OH; ;wherein R₄ is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; and ;wherein at least one of R₁, R₂, R₃₁ or R₄ is a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety. Optically pure enantiomers and salts of the compound are also described. Also, the synthesis of the compound, and uses of the compound, such as in a method for detecting the localization of, or identifying, receptors, enzymes or other targets, whether in a cell or in a subject.