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Novel crystalline disodium pamidronate hydrate and process for preparing it
Novel crystalline disodium pamidronate hydrate and process for preparing it
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机译:新型结晶帕米膦酸二钠水合物及其制备方法
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摘要
The present invention relates to a novel crystalline disodium pamidronate 34hydrate and a process for preparing it. More particularly, crystalline disodium pamidronate 34hydrate of the following formula I having the water content of 17.020.0 wt % and being in the state of the mixture of trihydrate and tetrahydrate is prepared by neutralizing pamidronic acid with sodium compound, drying the formed disodium pamidronate, dissolving the disodium pamidronate in water, filtering sparingly soluble materials, allowing the filtrate to stand with stirring at normal temperature to form crystals, cooling and filtering the mixture to obtain crystals, and drying at the temperature of 7585 C. under normal pressure. chemistry chemdraw filechemistry mol file;The novel disodium pamidronate 34 hydrate according to the present invention is much more stable compound structurally than the known disodium pamidronate pentahydrate. When the compound is in storage or is used as pharmaceutical formulations, validity time can be prolonged and it can be formulated as convenient oral preparations such as soft capsule in addition to injections.
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机译:本发明涉及新型的结晶的帕米膦酸二钠34水合物及其制备方法。更特别地,通过用钠化合物中和帕米膦酸,干燥形成的帕米膦酸二钠,制备水含量为17.020.0重量%并且处于三水合物和四水合物的混合物状态的下式I的结晶式帕米膦酸二钠34水合物,将帕米膦酸二钠溶解在水中,过滤微溶的物质,使滤液在常温搅拌下静置以形成晶体,冷却并过滤混合物以获得晶体,并在7585℃的常压下干燥。 <图像文件=“ US20020193627A1-20021219-C00001.GIF” he =“ 62.8803” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 120.74265” /> 化学chemdraw文件 ExternalFileRef> 化学mol文件<根据本发明的新型帕米膦酸二钠34水合物在结构上比已知的帕米膦酸二钠二水合物稳定得多。当该化合物贮存或用作药物制剂时,可以延长有效时间,并且可以将其配制成方便的口服制剂,例如除注射剂外的软胶囊。
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