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Methods and compositions for detecting and treating kidney diseases associated with adhesion of crystals to kidney cells
Methods and compositions for detecting and treating kidney diseases associated with adhesion of crystals to kidney cells
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机译:用于检测和治疗与晶体粘附于肾细胞有关的肾脏疾病的方法和组合物
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摘要
An autocrine crystal adhesion inhibitor called CAI is an anionic, sialic acid-containing glycoprotein secreted by kidney epithelial cells that blocks adhesion of calcium oxalate monohydrate (COM) crystals to the cell surfaces. Novel amino acid sequences are shown for the amino-acid terminus and 6 interval fragments. Persons may be classified according to risk of developing kidney stones, by measuring the amount of CAI in a biological sample. Treatment efficacy is also monitored by this method. CAI is administered in vivo to prevent nephrolithiasis. A rapid, simple assay to detect agents that inhibit adhesion of COM crystals to the surface of kidney epithelial cells is characterized.
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