Methods for the treatment of primary headache disorders using prostanoid EP4 receptor antagonists, and assays for agents for such treatment

摘要

The present invention provides for the treatment of primary headache disorders, particularly migraine, using antagonists of the EP₄ receptor for prostaglandin E2. Particular EP₄ receptor antagonists include azole compounds of formula (I): chemistry chemdraw filechemistry mol file;wherein R¹ is a group such as lower alkyl substituted with carboxy; R² is hydrogen or lower alkyl, R³ and R⁴ are aryl optionally substituted with halogen, chemistry chemdraw filechemistry mol file;in which —A¹— is a single bond or lower alkylene, chemistry chemdraw filechemistry mol file;is a cyclo group, ;—A³— is a single bond or lower alkylene, and X is O, NH or S; ;or a salt or its solvate thereof.