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Drug delivery system for enhanced bioavailability of hydrophobic active ingredients
Drug delivery system for enhanced bioavailability of hydrophobic active ingredients
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机译:增强疏水活性成分生物利用度的药物输送系统
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摘要
The present invention provides a drug delivery system for the oral administration of a hydrophobic active ingredient. The active ingredient's post-ingestion dissolution rate and its corresponding bioavailability can be optimized by intimately mixing a micronized hydrophobic drug with suitably sized inert particles to a dispersion that will facilitate desired bioavailability. In a particular embodiment, the hydrophobic active ingredient is fenofibrate. Suitably sized inert particles include microcrystalline cellulose and lactose. Dispersion may be monitored by microscopic visualization.
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