首页>
外国专利>
1,3,5- trisubstituted-1,3,5-triazine-2,4,6-trione compounds and libraries
1,3,5- trisubstituted-1,3,5-triazine-2,4,6-trione compounds and libraries
展开▼
机译:1,3,5-三取代-1,3,5-三嗪-2,4,6-三酮化合物和库
展开▼
页面导航
摘要
著录项
相似文献
摘要
The solid-phase synthesis of individual 1,3-disubstituted and 1,3,5-trisubstituted-1,3,5-triazine-2,4,6-triones and libraries thereof from a resin is described. Reaction of resin-bound amino acids with isocyanates yields resin-bound ureas, which further react with chlorocarbonyl isocyanate to selectively afford the resin-bound 1,3-disubstituted-1,3,5-triazine-2,4,6-triones. Selective alkylation at the N-5 position of the resin-bound 1,3-disubstituted-1,3,5-triazine-2,4,6-triones produces a trisubstituted triazinetrione. The products are cleaved from their solid support and obtained in good yield and purity.
展开▼