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METHODS FOR USING RESONANCE ENERGY TRANSFER- BASED ASSAY OF HIV-1 ENVELOPE GYLCOPROTEIN-MEDIATED MEMBRANE FUSION, AND KITS FOR PRACTICING SAME
METHODS FOR USING RESONANCE ENERGY TRANSFER- BASED ASSAY OF HIV-1 ENVELOPE GYLCOPROTEIN-MEDIATED MEMBRANE FUSION, AND KITS FOR PRACTICING SAME
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机译:基于共振能量转移的HIV-1包裹糖蛋白介导的膜融合测定方法及实用于该方法的试剂盒
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摘要
This invention provides: agents determined to be capable of specifically inhibiting the fusion of a macrophage-tropic primary isolate of HIV-1 to a CD4 cell, but not a T cell-tropic isolate of HIV-1 to a CD4 cell; and agents determined to be capable of specifically inhibiting the fusion of a T cell-tropic isolate of HIV-1 to a CD4 cell, but not a macrophage-tropic primary isolate of HIV-1 to a CD4 cell. This invention also provides: agents capable of specifically inhibiting the fusion of a macrophage tropic primary isolate of HIV-1 with a CD cell susceptible to infection by a macrophage-tropic primary isolate of HIV-1; and agents capable of specifically inhibiting the fusion of a T cell-tropic isolate of HIV-1 with a CD4 cell susceptible to infection by a T cell-tropic isolate of HIV-1. The agents include but are not limited to antibodies. This invention further provides: methods of inhibiting fusion of a macrophage-tropic primary isolate of HIV-1 with a CD cell susceptible to infection by a macrophage-tropic primary isolate of HIV-1 which comprises contacting the CD4 cell with an amount of an agent capable of specifically inhibiting such fusion so as to thereby inhibit such fusion; and methods of inhibiting fusion of a T cell-tropic isolate of HIV-1 with a CD4 cell susceptible to infection by a T cell-tropic isolate of HIV-1 which comprises contacting the CD4 cell with an amount of an agent capable of specifically inhibiting such fusion so as to thereby inhibit such fusion.
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