Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances

摘要

The invention relates to magnetic resonance imaging moieties, having increased in vivo residence time and amplified MRI signal, comprising a polymer and a plurality of activatable magnetic resonance imaging contrasting agents each attached to the polymer by a cleavable linkage; methods of detecting physiological signals or substances; and methods of drug delivery and drug detection for treatment of diseases.