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Delivery of Hypericum perforatum (St. John's Wort) in tablet form
Delivery of Hypericum perforatum (St. John's Wort) in tablet form
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机译:片状贯叶金丝桃(圣约翰草)的交付
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摘要
St. John's Wort has been indicated as a beneficial supplement to human diet. It has been traditionally provided as an extract, tincture, tea or capsule form, usually administered in amounts taken three times/day. It has been found that the manufacture of a tablet of this supplement material is a complex process, and that St. John's Wort extract is not amenable to wet tableting. A tablet which can be taken twice a day to provide a recommended supplemental level of St. John's Wort is described as comprising by weight of the tablet:;400 to 500 mg St. John's Wort extract as 57 to 75% by weight of the tablet,;1.0-5.0% by weight binder,;8-18% by weight dissolution regulator,;up to 30% by weight filler,;0.2 to 5.0% by weight glidant, and;0.5 to 2.5% by weight lubricant/glidant.;A process for manufacturing the tablet comprises the steps of;a) mixing components comprising:;400 to 500 mg St. John's Wort extract as 57 to 75% by weight of the tablet,;1.0-5.0% by weight binder,;8-18% by weight dissolution regulator,;up to 30% by weight filler,;and less than a final proportion of glidant and lubricant/glidant of 0.2 to 5.0% by weight glidant, and 0.5 to 2.5% by weight lubricant/glidant to form a slug,;b) breaking the slug down into particulates which can be subsequently compressed into a tablet,;c) adding sufficient glidant and/or lubricant glidant to form a composition with proportions of glidant and lubricant/glidant of 0.2 to 5.0% by weight glidant, and 0.5 to 2.5% by weight lubricant/glidant, and;d) compressing the composition to form a tablet.
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