Paramagnetic and active analogue (EMP-2) of melanocyte stimulating hormone containing amino acid-type stable free radical

摘要

The present invention relates to an -melanocyte stimulating hormone (-MSH) analogue, labeled with an amino acid-type paramagnetic spin probe, for example, Toac, or 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid, and methods for the synthesis thereof. The preferred analogue of the invention, acetyl-Toac⁰--MSH (abbreviated as EPM-2) is the first such analogue that maintains entirely the natural -MSH activity.