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Pulsatile acidification wave demineralization process for producing osteoinductive bone; and osteoinductive bone produced thereby
Pulsatile acidification wave demineralization process for producing osteoinductive bone; and osteoinductive bone produced thereby
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机译:脉冲酸化波脱盐过程生产骨诱导性骨;和由此产生的骨诱导性骨
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摘要
The invention is directed to a process for producing demineralized osteoinductive bone, and demineralized osteoinductive bone produced thereby. The process achieves demineralization of bone by subjecting bone, including for example ground bone, bone cubes, chips, strips, or essentially intact bone, to a rapid high volume, pulsatile acidification wave process. The process includes subjecting bone to two or more rapid pulse/drain cycles where one or more demineralizing acids are rapidly pulsed into a vessel containing bone, and after a desired period of time, is rapidly drained from the vessel, the vessel containing the bone is then rapidly refilled with the one or more demineralizing acids (pulsed). The process allows bone to be rapidly demineralized to a precise ans specific desired residual calcium level, without sacrificing osteoinductivity.
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