Methods of determining SAM-dependent methyltransferase activity using a mutant SAH hydrolase

摘要

The present invention relates to compositions and methods for assaying the activity of methyltransferases, such as S-adenosylmethionine (SAM)-dependent methyltransferases. The methods can be used for screening for modulators of such methyltransferases, for identifying substrates and for diagnostics. The methods are amenable for use in high throughput formats. Kits for performing the methods are also provided.