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Methods for determining chemosensitivity of cancer cells based upon expression of negative and positive signal transduction factors
Methods for determining chemosensitivity of cancer cells based upon expression of negative and positive signal transduction factors
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机译:基于阴性和阳性信号转导因子的表达确定癌细胞化学敏感性的方法
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摘要
Provided is a method for measuring the sensitivity of a cancer cell to an anticancer agent, which method comprises testing a sample for the mutational status, expression, and/or function of a negative signal transduction factor (NSTF), and testing the sample for the mutational status, expression, and/or function of a positive signal transduction factor (PSTF), wherein when the method comprises measuring the radiosensitivity of wild-type p53 cancer cells by testing a sample comprising wild-type p53 cells or an extract therefrom for the abundance of Raf-1 protein by Western blotting, an antibody specific to Raf-1 protein is employed.
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