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Synthesis, lipid peroxidation and cytotoxic evaluation of 10-substituted 1,5-dichloro-9(10H)-anthracenone derivatives
Synthesis, lipid peroxidation and cytotoxic evaluation of 10-substituted 1,5-dichloro-9(10H)-anthracenone derivatives
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机译:10-取代的1,5-二氯-9(10H)-蒽酮衍生物的合成,脂质过氧化和细胞毒性评估
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摘要
The present invention is the synthesis of a series of 1,5-dichloro-9(10H)-anthracenones bearing O-linked and N-linked substituents in the 10-position. These compounds were evaluated for their ability to inhibit the growth of the human oral epidermoid carcinoma cells (KB cell line), human cervical carcinoma cells of ME 180 (GBM 8401) and Chinese hamster ovary cells (CHO), respectively. In addition, redox property of the compounds for inhibition of lipid peroxidation in model membranes was determined. 展开▼
机译:本发明是一系列在10位带有O-和N-取代基的1,5-二氯-9(10H)-蒽酮的合成。分别评估了这些化合物抑制人口腔表皮样癌细胞(KB细胞系),ME 180的人宫颈癌细胞(GBM 8401)和中国仓鼠卵巢细胞(CHO)生长的能力。另外,测定了化合物在模型膜中抑制脂质过氧化的氧化还原性质。 <图像alt =“嵌入式图像” file =“ US06596774-20030722-C00001.GIF” he =“ 83.03715” id =“ EMI-C00001” imgContent =“ undefined” imgFormat = “ GIF” wi =“ 84.73815” /> 化学>
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