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System for reproducing and modulating stability and turnover of RNA molecules
System for reproducing and modulating stability and turnover of RNA molecules
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机译:用于复制和调节RNA分子稳定性和周转的系统
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摘要
An in vitro system is provided that recapitulates regulated mRNA stability and turnover of exogenous RNA substrates. The system comprises a cell extract optionally depleted of activity of proteins that bind polyadenylate, and a target RNA sequence. This system is used for the identification of agents capable of modulating RNA turnover, as well as agents capable of modulating RNA turnover in the presence of RNA stability modifying agents.
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