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Capillary electrophoretic method to detect target-binding ligands and to determine their relative affinities
Capillary electrophoretic method to detect target-binding ligands and to determine their relative affinities
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机译:毛细管电泳法检测目标结合配体并确定其相对亲和力
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摘要
The invention relates to capillary electrophoretic methods for detecting ligands or hit compounds that can bind to a selected target at or above a selected binding strength. The method allows one to rank various ligands based on their relative affinity, i.e., the relative stability of the target/ligand complex during capillary electrophoresis under selected conditions. The method also enables selective detection of strong-to-moderate binding hit compounds, even in the presence of high concentrations of weaker, competitive hit compounds.
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