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Anti-apoptotic compositions comprising the R1 subunit of herpes simplex virus ribonucleotide reductase or its N-terminal portion; and uses thereof
Anti-apoptotic compositions comprising the R1 subunit of herpes simplex virus ribonucleotide reductase or its N-terminal portion; and uses thereof
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机译:抗凋亡组合物,其包含单纯疱疹病毒核糖核苷酸还原酶的R1亚基或其N端部分;及其用途
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摘要
An anti-apoptotic agent and a composition derived therefrom, and methods to prevent apoptosis in vivo and in vitro are provided. The anti-apoptotic agent comprises R1 subunit of Herpes simplex virus (HSV) ribonucleotide reductase, or its N-terminal portion of about 350 amino acids. HSV-R1 inhibited TNF- induced apoptosis, and blocked caspase 8 activation induced by TNF- and Fas-L expression.
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