amp;bgr;-polypeptide foldamers of well-defined secondary structure

摘要

Disclosed are &bgr;-peptides containing cylcoalkyl, cycloalkenyl, and heterocylic substituents which encompass the &agr; and &bgr; carbons of the peptide backbone. The &bgr;-peptides adopt stable helical and sheet structures in both the solid state and in solution. Method of generating combinatorial libraries of peptides containing &bgr;-peptide residues and the libraries formed thereby are disclosed.