One pot synthesis of amp;lsqb;2,8-Bis (trifluoromethyl)-4-quinolinylamp;rsqb;-2-pyridinylmethanone, a mefloquine intermediate

摘要

The present invention provides a simple single step process for the preparation of [2,8-bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone, comprising the step of condensing a halo-quinoline with an alpha-picolyl derivatives in the presence of a solvent, a base and a phase transfer catalyst at −10° C. to +90° C.