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Synthesis of N-amp;lsqb;N-(3,3-dimethylbutyl)-L-amp;agr;-aspartylamp;rsqb;-L-phenylalanine 1-methyl ester using L-amp;agr;-aspartyl-L-phenylalanine 1-methyl ester precursors
Synthesis of N-amp;lsqb;N-(3,3-dimethylbutyl)-L-amp;agr;-aspartylamp;rsqb;-L-phenylalanine 1-methyl ester using L-amp;agr;-aspartyl-L-phenylalanine 1-methyl ester precursors
N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of a mixture of 3,3-dimethylbutyraldehyde and a precursor of L-&agr;-aspartyl-L-phenylalanine 1-methyl ester. In particular, N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester is produced using an acid salt of L-&agr;-aspartyl-L-phenylalanine 1-methyl ester or N-protected L-&agr;-aspartyl-L-phenylalanine 1-methyl ester. The production method is efficient and low cost, as compared with conventional N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester synthesis.
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