Photocleavable and acid cleavable linkers for combinatorial chemistry

摘要

A substrate for solid phase synthesis comprising a solid phase-linker combination of the formula I is disclosed. Also disclosed are processes for preparing the substrate and chemical intermediates useful therein. Among the novel intermediates are compounds of the formula II wherein R¹ is NO₂ or CHO; R² is OCH₃, CHO or H; R³ is chosen from the group consisting of hydroxyl, the residue of a solid support having a plurality of amino groups, and the residue of an ester, and n1 or 3-12. ;A substrate of solid phase synthesis of the formula III is also disclosed.