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Process for the preparation of pharmacologically active amp;agr;-asarone from toxic amp;bgr;-asarone rich acorus calamus oil
Process for the preparation of pharmacologically active amp;agr;-asarone from toxic amp;bgr;-asarone rich acorus calamus oil
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机译:从有毒的-aasarone的a蒲cal蒲油中制备药理活性-a-asarone的方法
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摘要
The present invention relates to a process for the preparation of high purity and yield &agr;-asarone, trans 2,4,5-trimethoxy cinnamaldehyde, 2,4,5-trimethoxy-phenyl propionone, from &bgr;-asarone or &bgr;-asarone rich Acorus calamus oil containing &agr; and &ggr;-asarone by hydrogenating, followed by treatment with DDQ with or without solid support of silica gel or alumina in dry organic solvent and &agr;-asarone can also be obtained by treating the hydrogenated product of &bgr;-asarone or &bgr;-asarone rich Acorus calamus with DDQ in an aqueous organic solvent to obtain an intermediate 2,4,5-trimethoxy phenyl propionone, which in turn is reduced with sodiumborohydride to obtain the corresponding 2,4,5-trimethoxy-phenyl propanol and followed by final treatment with a dehydrating agent.
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