8A and 9a lactams of 15 members of the Class 6 - or Methyl Erythromycin A,A process for their Preparation and Pharmaceutical composition useful for the treatment of bacterial infections in humans and Animals

摘要

It refers to the new 8s - and 9s lactamans, 6-o-methyl-erythromycin a (1) and its inorganic or organic acid drug acceptable drug addictive salt and its hydrate, wherein a represents an NH and B represents a C group at the same time = or, O a represents group C = group O, and group B represents group NH at the same time. R1 represents an OH group, an l-cladinosilo de design (2) or R1 represents a group of formulas (3), which contain hydrogen, C1-6 tar, a group of C1-6 tar, at least one atom contained in O, n or s, or (CH2) n-ar (CH2), n represents tar, n represents 1-10, with or without atoms,Incorporated N or S, and Ar represents a 5 û 10 membered monocyclic or bicyclic aromatic ring containing 0-3 atoms of O, N or S, substituted or unsubstituted by 1 û 3 groups representing halogen, OH, OMe, NO2, NH2, amino C1-3alkyl or C1-3 amino dialkyl, CN, SO2NH2, C1-3alkyl, or R1 together with R2 represents ketone, R2 represents hydrogen or together with R1 represents ketone, R3 represents hydrogen or a C1- alkanoyl group 4, R4 represents hydrogen or together with R5 represents ketone, R5 represents OH, NH2, amino C1-3alkyl or amino C1-3 dialkyl, O (CH2) nAr or S (CH2) nûAr, where (CH2) n and Ar have the meanings given previously, or together with R4 represent ketone,R6 represents hydrogen, C1-6 tar, C1-6 tar group, which has at least one or more atoms or one or more atoms contained, or a N2 group in which (CH2) n and AR have the meanings previously given, or R5 and R6, together with the atoms involved, form an additional molding ring (4a) and (4b).