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A method for the treatment of overactive bladder with unstable or a controlled release formulation of Tolterodine or related compounds, the pharmaceutical Formulation and useTolterodine or related compounds.
A method for the treatment of overactive bladder with unstable or a controlled release formulation of Tolterodine or related compounds, the pharmaceutical Formulation and useTolterodine or related compounds.
A method and Formulation for the treatment of unstable or overactive bladder.In which is given to a patient or a pharmaceutically effective amount of Detrol Tolterodine or a related compound, a pharmaceutically acceptable Salt of the same,By means of a controlled release formulation, capable of maintaining an average Serum level of activity or activities substantially Constant for at least 24 hours.A Pharmaceutical formulation containing Detrol Tolterodine or a related compound, or a pharmaceutically acceptable Salt thereof,Controlled release of Detrol Tolterodine or a related compound, or Salt of the same when administered to patients.Preferably, the controlled release formulation provides an Index of average fluctuation of the average Serum level of activity or activities that are not of approximately 2.0 preferably not greater than about 1.0 being defined the index fluctuation, Fi, FI = (Cmax Cmin / t) / AUCt and Cmax and Cmin is the minimum and maximum concentrations, respectively.Half of the activity or activities, AUCt is the area under the Serum concentration profile and t is the length of the dosing interval.The use of Detrol Tolterodine or a related compound, or a pharmaceutically acceptable Salt thereof for the manufacture of a controlled release Formulation for Therapeutic andL Treatment of unstable or overactive bladder.
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