Combination of Drugs not InteractivePharmaceutical Formulation and Pharmaceutical Package comprising such a combination and the use of the HMGCoA reductase inhibitor in preparation of Medicine used in combination Therapy

摘要

Drug combinations of non Interactive Secure an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA reductase),What is acid (e) - [4 - (4-fluorophenyl) - 6 - [METHYL ISOPROPYL 2 - (methylsulfonyl) amino] pyrimidin-5-yl] (3R, 5S) - 35 - 6 dihidroxihept acid or a pharmaceutically acceptable Salt thereof (the agent) and a drug which is an Inducer, inhibitor or substrate of cytochrome P450In particular, the 34th isozyme of cytochrome P450. Pharmaceutical formulations and Pharmaceutical packages comprising such combinations are also described.The reductase Inhibitor, acid (e) - 7 - [4 - (4-fluorophenyl) - 6 - [METHYL ISOPROPYL 2 - (methylsulfonyl) amino] pyrimidin-5-yl] (3R, 5S) - 35 - 6 - dihidroxihept acid or a pharmaceutically acceptable Salt thereof, used in the preparation of a Medicine for use in combination Therapy with a Second Drug is an Inducer.Inhibitor or substrate of cytochrome P450 isoenzyme 34th.Medicines comprising These particular combinations are useful in the treatment of hyperlipidemia and cardiovascular conditions in humans.