Proliposomas Powder, a process for the preparation of these proliposomas Powder, Process for the preparation of a Pharmaceutical composition using proliposomas Powder and apparatus to be used in the preparation of such proliposomas Powder

摘要

Proliposomas Powder, a process for the preparation of these proliposomas Powder, Process for the preparation of a Pharmaceutical composition using proliposomas Powder and apparatus to be used in the preparation of such proliposomas Powder.The composition comprises a mixture of proliposomas Powder phospholipid Phase Transition Temperature of 37 degree C. The amount of phospholipids is between 60 and 80% by weight of the total weight of the composition, and a Moisture content less than 10%.The Procedure for the preparation of a Pharmaceutical composition comprising such proliposomas rehydrate with stirring an aqueous solution that contains an active substance at a temperature of between 55 and 75 and 180 Degree C for 60 minutes.The Apparatus to be used in the procedure for making the proliposomas Powder comprises a dehydration Chamber hermetically closed, in whose interior is housed a rotating Stirrer formed by Blades fixed to a Shaft connected to the Drive means.Circling around the heating Chamber for heating are arranged in bands of Liposomes to dehydrate. The Camera includes a Nozzle for Connecting means Vacuum generators inside it and for Loading the product to Dry.The Camera features a lockable Door Lock, which is fixed through hinges and Regulatory Impediments perpendicular with respect to the longitudinal Axis of the camera Geometry.