Method to improve the compressibility of a super-disintegrant, obtain a complex of highly compatible super-disintegrating drug preparation, increased super-disintegrant and its solid dosage form

摘要

"METHOD TO IMPROVE THE COMPRESSIBILITY OF A SUPERDESINTEGRANT, TO OBTAIN A HIGHLY COMPATIBLE, SUPERDESINTEGRANT DRUG PREPARED COMPLEX, ENHANCED SUPERDESINTEGRANT AND SOLID DOSE FORM". Where the method is understood by: a) temporarily opening said particles; and b) adding an enhancing agent that increases the properties of the super disintegrant in relation to the unmodified particles of the super disintegrant, c) reducing the elasticity of said particles of disintegrant making the core of said particles more hydrophobic; said super-disintegrant particles being selected from the group consisting of starch materials and cellulosic materials or from the group consisting of cross-linked sodium carboxymethyl starch and cross-linked sodium carboxymethyl cellulose.