Specific binding element, isolated nucleic acid, host cell, methods for producing a specific binding element or domain vh or vl of antibody, and, to obtain a specific binding element that binds eotaxin

摘要

"SPECIFIC CONNECTION ELEMENT, ISOLATED NUCLEIC ACID, HOST CELL, METHODS TO PRODUCE ANTIBODY VH OR VL CONNECTION DOMAIN, AND TO OBTAIN A SPECIFIC EFFECTIVE LINK ELEMENT" Specific binding elements directed to eotaxin-1, particularly human antibodies and antibody fragments against human eotaxin-1 and especially those that neutralize eotaxin-1 activity. The VH and / or VL domains of fg scFv antibodies, herein referred to as CAT-212, and those of IgG4 antibodies, herein called CAT 213. One or more complementary VH and / or VL domain determination regions (CDRS) of CAT212 / 213 , especially VH CRD3, in other antibody framework regions. Compositions containing specific binding elements and their use in methods for inhibiting or neutralizing eotaxin, including methods of treatment of the human or animal body by therapy.