Compound, pharmaceutical composition, method of preparing pharmaceutical compositions, process for preparing compounds, and methods for treating psychiatric, gastrointestinal and cardiovascular disorders

摘要

"COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD FOR PREPARATION OF PHARMACEUTICAL COMPOSITIONS, PROCESS FOR PREPARATION OF COMPOUNDS, AND METHODS FOR TREATMENT OF PSYCHITRIC DISTURESIS, AND DYSTRIBUS DISTURES DISTURES; The present invention relates to a group of novel 4,5-dihydro-1H-pyrazole derivatives which are potent Cannabis CB-1 receptor antagonists. The compounds have general formula (I) wherein R and R1 are the same or different and represent phenyl, thienyl or pyridyl, which groups may be substituted with 1.2 or 3 Y substituents, or R and / or R3. R1 represents naphthyl, R2 represents hydrogen, hydroxy, C1-3 alkoxy, acetyloxy or propionyloxy, Aa represents one of (i), (ii), (iii), (iv) or (v) Bb represents sulfonyl or carbonyl, R 3 represents benzyl, phenyl, thienyl or pyridyl which may be substituted with 1, 2 or 3 substituents Y or R 3 represents C 1-8 branched or unbranched alkyl or C 3-8-cycloalkyl or R3 represents naphthyl.