Composition of matter, nucleic acid, expression vector, host cell, process for preparing a pth / pthrp receptor antagonist, and method of treating osteopenia

摘要

"MATTER COMPOSITION, NUCLEIC ACID, EXPRESSION VECTOR, HOST CELL, PROCESS FOR PREPARING A PTH / PTHRP RECEIVER ANTAGONIST, AND METHOD OF TREATING OSTEOPENIA". The present invention relates to therapeutic agents that modulate PTH and PTHrP activity. In accordance with the present invention, PTH and PTHrP modulators comprise: (a) a PTH / PTHrP modulator domain; and (b) a carrier, such as a polymer (e.g. PEG or dextran) or an Fc domain, which is preferred: wherein the carrier is covalently linked to the C-terminus of the PTH / PTHrP modulator domain. The vehicle and the PTH / THrP modulating domain may be linked through the N or C terminus of the PTH / THrP modulating domain as described below. The preferred vehicle is an Fc domain and the preferred Fc domain is an IgG Fc domain. Preferred PTH / PTHrP modulator domains include the PTH and PTHrP derived amino acid sequences described below. Other PTH / PTHrP modulating domains may be generated by phage demonstration, RNA-peptide screening and other techniques mentioned herein. Such peptides will typically be modulators of both PTH activity and PTHrP activity, although such techniques may be used to generate peptide sequences that serve as selective modulators (eg, agonists of PTH activity but not PTHrP activity).