Pharmaceutical composition, use of a sterile pharmaceutical composition, and method for improving survival in a critically ill patient

摘要

"PHARMACEUTICAL COMPOSITION, USE OF A STERILE PHARMACEUTICAL COMPOSITION, AND METHOD TO IMPROVE SURVIVAL IN A CRITICALLY SICK PATIENT". The invention relates to a method of treating and improving survival in critically ill patients and the use of certain sterile sedative pharmaceutical compositions for the manufacture of a medicament for improving the survival of such patients; in particular such use of pharmaceutical compositions comprising a free radical scavenging agent (such as propofol) and a metal ion chelating agent (such as edetate) in combination with a pharmaceutically acceptable diluent or carrier, especially such a composition comprising an emulsion of oil in water wherein the propofol is dissolved in a water immiscible solvent and emulsified with water and stabilized by a surfactant and further comprises a metal ion chelating agent (such as disodium edetate).