Indole and benzimidazole as 15-lipoxygenase inhibitors

摘要

"INDOL AND BENZIMIDAZOLE AS 15-LIPOXYGENASE INHIBITORS". This invention relates to indole and benzimidazole 15-lipoxygenase (15-LO) inhibitors of formula (I), wherein one of Y ~ 1 ~ and Y ~ 2 ~ is CH, N, or NH and the other is (a) or (b); R3 includes H, halo, NH2, COOH, alkyl; R4 includes halo, alkyl and alkoxy; Z is C, CH, or NR 5 ~; R 5 is H or oxycarbonyl; and each Y is independently H, alkyl, alkoxy or halo.