Low rigidity multilamellar liposomal formulation The process of treating or prophylaxis a bacterial infection in an animal and a mucoid variant thereof, using the antibacterial liposomal formulation

摘要

"LOW-RIGID MULTI-FAMILY LIPOSOMAL FORMULATION FOR THE PROCESS OF TREATMENT OR PROPHYLAXIS OF A BACTERIAL INFECTION IN AN ANIMAL AND MUCOID VARIANT OF THE SAME, USE OF LIPOSOMAL FORMULATION AND ANTIBACY FORMULATION". The invention relates to a liposomal formulation containing at least one therapeutic agent such as an antibiotic and a method of treating bacterial infections by administering such a formulation. A cholesterol-free, low-rigidity multilamellar liposomal formulation comprising a neutral lipid, an anionic lipid and at least one therapeutic agent is provided, wherein the liposomal formulation improves the penetration of the therapeutic agent into a bacterial cell. A preferred lipid combination is dipalmitoylphosphatidylcholine (DPPC): dimyristoylphosphatidyl glycerol (DMPG) at a ratio of 10: 1 to 15: 1, with total lipid concentration ranging from 5 to 85 mM.