Process for the preparation of (3 - 4 - fluoro chloro phenyl) - 7 - (3 - - 4 - - Morpholine yl propoxy) - 6 - nitroquinazolina yl - 4 - (Amine or fluorofenilo 3-chloro-4 - 7 - (3) - Morpholine - il - 4 - aminoquinazo propoxy) - 6 -Lina - 4 - yl - amine

摘要

Process for the preparation of (fluorofenilo 3-chloro-4 - [7 - (3) - Morpholine yl - - 4 - - nitroquinazolina propoxy) - 6 - 4 - yl] - Amine (i) EMI file = "01014681 _ 1" id = "1" IMF ( OR = JPEG 3-chloro-4 fluorofenilo) - 7 - [(3 -Morpholine - 4 - ILO - aminoquinazolina propoxy) - 6 - 4 - yl] - Amine (vii) EMI file = "01014681 _ 2" id = "2" mfi = JPEG, characterized in that, in a Global reaction in 3 or 4 stages of reaction.A First reacts nitroquinazolina - fluoro - 6 - 7 - 4 (3H) - One (iii) EMI file = "01014681 _ 3" id = "3" = JPEG MFIs with thionyl chloride to Give 4 - Chloro - fluoro - 6 - 7 - nitroquinazolina (iv) file = "01014681 EMI _4 "id =" 4 " MFI = JPEG and reacts with 3-chloro-4 fluoroanilina to Give 4 - (3-chloro-4 fluoroanilina) - 7 - (4-fluoro-6 - nitroquinazolina v).File = " EMI 01014681 _ 5" id = "5" mfi = JPEG and subsequently with Morpholine - 3 - 4 - 1 - ILO - propane - ol (VI) EMI file = "01014681 _ 6" id = "6" mfi = JPEG for (i) and (possibly) (i) directlyThe reaction solution to (iii).