Recombinant immunotoxins comprising a Link domain of CDs, and a Mutant of Pseudomonas exotoxin a and therapeutic uses for the same

摘要

The present Invention relates to a polypeptide comprising a recombinant inmutoxina Link domain of CD3 and a Mutant of Pseudomonas exotoxin, and in particular, comprising of a single Chain FV (SC) as the fraction of link of CD3. The Invention comprises a Preferred species scFv (ucht - (1) - pe38.Also disclosed are methods for the preparation of these immunotoxins; immunotoxins functionally equivalent are Intermediates in the preparation of the immunotoxin of Invention, as well as intermediaries of oligonucleotides and polynucleotides, Methods for Prevention and / the treatment of Transplant rejection or Tolerance Induction.As well as the treatment of autoimmune Disorders and other immune disorders, immunotoxins or pharmaceutically acceptable salts using the same, and Pharmaceutical compositions comprising the immunotoxins or pharmaceutically acceptable salts thereof.