Not peptidilicos of inhibitors Binding to cells attached to Teeth of vla-4 useful in the treatment of autoimmune and inflammatory diseases, respiratory

摘要

Compound of formula (1.0 are described.File = " 0) EMI 99040934 _ 1" id = "1" = MFIs and their pharmaceutically acceptable salts, JPEG and other Derivatives of prodrugs thereof, in which a is aryl, heteroaryl or heterocycle, as defined here, and such Heterocyclic substituted aryl, heteroaryl or with 0 to 3 R10 is a wed; or Member selected from the group consisting of: - a1nhc divalent radical (= o) NH - 2 -, a1nhc (= o) - O - 2 -And a1nh (NCN) - NH - 2 - and each of A1 and A2 irrespective of the group consisting of hydrogen, aryl, heteroaryl and heterociclilo as defined here, while these aryl,Heteroaryl substituted with heterocycle or 3 - 0 to 10; b is a member selected from the group consisting of independently the following: EMI file = "99040934 _ 2" id = "2" mfi = JPEG - - Where the symbol "*" indicates the point of Union of the radical represented by each of the formulae partial ( 1.1.0) (Textile), the radical "and" in the formula (1.0.0); and the symbol "?" Indicates the point of Union of the radical represented by each of the partial Solutions (1.1.0) (Textile) "and" The Radical of formula (1.0.0);...