Podophyllotoxin carbamate and thiocarbamate derivatives, process of their preparation and pharmaceutical preparations in which the derivatives are comprised

摘要

Carbamate and thiocarbamate podophyllotoxin derivatives (I), their enantiomers, diastereoisomers, and their salts with acids and bases. Carbamate and thiocarbamate podophyllotoxin derivatives (I), their enantiomers, diastereoisomers, and their salts with acids and bases R1 = H, 1-6C alkyl, aryl, aryl 1-6C alkyl, heteroaryl, heteroaryl 1-6C alkyl, 1-6C alkoxy carbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, 1-6C alkylsulfonyl, arylsulfonyl, arylalkyl sulfonyl, or phosphonic; R2 = O or S; R3 = H, 1-6C alkyl, cycloalkyl, or aryl 1-6C alkyl; X = 1-6C alkylene; R4 = amino (optionally substituted by one or two groups selected from alkyl, aryl, and aralkyl), -N(R3)-X1-OR5, -N(R3)-X1-NR6R7, OH, 1-6C alkoxy, aryloxy, -O-X1-OR5, or -O-X1-NR6R7; X1 = 1-6C alkylene; R5 = H, 1-6C alkylaryl, or aryl 1-6C alkyl; R6 and R7 = H, 1-6C alkyl, aryl, or aryl 1-6C alkyl .