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L-Nucleosides intended for treating hepatitis B virus (HBV) and Epstein-Barr virus (EBV)

机译:用于治疗乙型肝炎病毒(HBV)和爱泼斯坦-巴尔病毒(EBV)的L-核苷

摘要

In the present invention there is disclosed L-nucleoside of the general formula I, in which R represents 5-methyl uracil, adenine or cytosine residues, R'' represents a hydrogen atom, acetyl, propionyl, butyryl, pentanoyl, 3-methylbutyryl, benzoyl or pivaloyl group or it can also represents an alkyl group containing 1 to 10 carbon atoms or mono-, di or triphosphate alkyl ester or phenyl alkyl ester group having 1 to 10 carbon atoms in the alkyl moieties, further pharmaceutically acceptable salts thereof. These compounds are efficient substances for a pharmaceutical preparation intended for treating a host infected with hepatitis B virus (HBV) and Epstein-Barr virus (EBV).
机译:在本发明中,公开了通式I的L-核苷,其中R代表5-甲基尿嘧啶,腺嘌呤或胞嘧啶残基,R''代表氢原子,乙酰基,丙酰基,丁酰基,戊酰基,3-甲基丁酰基,苯甲酰基或新戊酰基或其还可以代表在烷基部分中具有1至10个碳原子的烷基或具有1至10个碳原子的单,二或三磷酸烷基酯或苯基烷基酯基。这些化合物是用于药物制剂的有效物质,该药物制剂旨在治疗感染了乙型肝炎病毒(HBV)和爱泼斯坦巴尔病毒(EBV)的宿主。

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